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Tumour heterogeneity: the key advantages of single-cell analysis
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2017, 17, pp.2142-2142. ⟨10.3390/ijms17122142⟩, International Journal of Molecular Sciences, 2017, 17, pp.2142-2142. ⟨10.3390/ijms17122142⟩, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, International Journal of Molecular Sciences, Vol 17, Iss 12, p 2142 (2016)
- Publication Year :
- 2016
- Publisher :
- MDPI, 2016.
-
Abstract
- International audience; Tumour heterogeneity refers to the fact that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. This phenomenon occurs both between tumours (inter-tumour heterogeneity) and within tumours (intra-tumour heterogeneity), and it is caused by genetic and non-genetic factors. The heterogeneity of cancer cells introduces significant challenges in using molecular prognostic markers as well as for classifying patients that might benefit from specific therapies. Thus, research efforts for characterizing heterogeneity would be useful for a better understanding of the causes and progression of disease. It has been suggested that the study of heterogeneity within Circulating Tumour Cells (CTCs) could also reflect the full spectrum of mutations of the disease more accurately than a single biopsy of a primary or metastatic tumour. In the last years many high throughput methodologies have raised for the study of heterogeneity at different levels (i.e.: RNA, DNA, protein, epigenetic events). The aim of the current review is to stress clinical implications of tumour heterogeneity, as well as current available methodologies for their study with a specific attention to those able to assess heterogeneity at the single cell level.
- Subjects :
- 0301 basic medicine
Tumour heterogeneity
circulating tumour cells
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease
Review
Biology
Bioinformatics
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
Genetic Heterogeneity
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Single-cell analysis
[SDV.CAN] Life Sciences [q-bio]/Cancer
single cells
Neoplasms
Gene expression
Biopsy
medicine
Humans
Epigenetics
Physical and Theoretical Chemistry
Neoplasm Metastasis
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
medicine.diagnostic_test
Organic Chemistry
General Medicine
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Neoplastic Cells, Circulating
Phenotype
3. Good health
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Cancer cell
Cancer research
Single-Cell Analysis
heterogeneity
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2017, 17, pp.2142-2142. ⟨10.3390/ijms17122142⟩, International Journal of Molecular Sciences, 2017, 17, pp.2142-2142. ⟨10.3390/ijms17122142⟩, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, International Journal of Molecular Sciences, Vol 17, Iss 12, p 2142 (2016)
- Accession number :
- edsair.doi.dedup.....beb0ad762b52435c5431e5de6b98eb90