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Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese men
- Source :
- International Journal of Obesity. 35:448-456
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Previous patterns of energy intake influence gastrointestinal function and appetite, probably reflecting changes in small-intestinal nutrient-mediated feedback. Obese individuals consume more fat and may be less sensitive to its gastrointestinal and appetite-suppressant effects than lean individuals.To evaluate the hypothesis that, in obese individuals, the effects of duodenal fat on gastrointestinal motor and hormone function, and appetite would be enhanced by a short period on a very-low-calorie diet (VLCD).Eight obese men (body mass index 34±0.6 kg m(-2)) were studied on two occasions, before (V1), and immediately after (V2), a 4-day VLCD. On both occasions, antropyloroduodenal motility, plasma cholecystokinin (CCK), peptide-YY (PYY) and ghrelin concentrations, and appetite perceptions were measured during a 120-min intraduodenal fat infusion (2.86 kcal min(-1)). Immediately afterwards, energy intake was quantified.During V2, basal pyloric pressure and the number and amplitude of isolated pyloric pressure waves (PWs) were greater, whereas the number of antral and duodenal PWs was less, compared with V1 (all P0.05). Moreover, during V2, baseline ghrelin concentration was higher; the stimulation of PYY and suppression of ghrelin by lipid were greater, with no difference in CCK concentration; and hunger and energy intake (kJ; V1: 4378±691, V2: 3634±700) were less (all P0.05), compared with V1.In obese males, the effects of small-intestinal lipid on gastrointestinal motility and some hormone responses and appetite are enhanced after a 4-day VLCD.
- Subjects :
- Male
medicine.medical_specialty
Duodenum
Endocrinology, Diabetes and Metabolism
food.diet
media_common.quotation_subject
Medicine (miscellaneous)
Body Mass Index
Gastrointestinal Hormones
food
Internal medicine
medicine
Humans
Obesity
Caloric Restriction
media_common
Nutrition and Dietetics
Gut motility
Appetite Regulation
business.industry
Appetite
Fasting
Middle Aged
medicine.disease
Small intestine
Very low calorie diet
medicine.anatomical_structure
Endocrinology
Energy Intake
Gastrointestinal Motility
business
Body mass index
Biomarkers
Hormone
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....be9c515c52ce349430dbdfbeddbeb417