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Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study
- Source :
- Investigative ophthalmology & visual science, 48(7), 3014-3018. Association for Research in Vision and Ophthalmology Inc., Investigative Ophthalmology & Visual Science, 48, 3014-3018. Association for Research in Vision and Ophthalmology Inc.
- Publication Year :
- 2007
-
Abstract
- PURPOSE. Retinal venular dilatation is associated with systemic inflammation. The hypothesis for the current study was that larger retinal venular diameters are related to the His allele of the Tyr402His polymorphism in the complement factor H (CFH) gene, a major inhibitor of the complement pathway. Possible effect modification by smoking and inflammatory markers was examined. METHODS. This cross-sectional study was performed within the Rotterdam Study, a population-based study among elderly persons aged 55 years and older. The Tyr402His polymorphism of the CFH gene was genotyped in 5066 participants and retinal arteriolar and venular diameters were graded on digitized fundus transparencies. RESULTS. Genotype frequencies were 41% in TyrTyr, 45% in TyrHis, and 14% in HisHis carriers. The His 402 allele was associated with smaller rather than larger venular diameters (ageand sex-adjusted means and standard errors [in micrometers] were 222.5 0.45 for TyrTyr, 221.9 0.43 for TyrHis, and 220.6 0.78 for HisHis carriers; P-trend 0.03). This association was apparent only in never-smokers and was not modified by the inflammatory markers erythrocyte sedimentation rate, leukocyte count, C-reactive protein, or fibrinogen. Adjustment for cardiovascular risk factors did not change results. No associations were found with arteriolar diameters. CONCLUSIONS. The findings do not support the hypothesis that the His 402 allele is related to larger retinal venular diameters. The association with smaller retinal venular diameters most likely is a chance finding, because it was present only among never-smokers and was not modified by inflammatory mediators of complement. These results suggest that the Tyr402His variant is not related to retinal venular diameters. (Invest Ophthalmol Vis Sci. 2007;48:3014‐3018) DOI:10.1167/iovs.061460
- Subjects :
- Male
medicine.medical_specialty
Genotype
Population
Blood Sedimentation
Fibrinogen
Rotterdam Study
chemistry.chemical_compound
Ophthalmology
medicine
Humans
Histidine
Prospective Studies
education
Alleles
Aged
Netherlands
education.field_of_study
Polymorphism, Genetic
biology
business.industry
C-reactive protein
Smoking
Retinal Vessels
Retinal
Middle Aged
Complement system
Genotype frequency
Vasodilation
C-Reactive Protein
Cross-Sectional Studies
chemistry
Factor H
Complement Factor H
Immunology
biology.protein
cardiovascular system
Female
Inflammation Mediators
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 01460404
- Database :
- OpenAIRE
- Journal :
- Investigative ophthalmology & visual science, 48(7), 3014-3018. Association for Research in Vision and Ophthalmology Inc., Investigative Ophthalmology & Visual Science, 48, 3014-3018. Association for Research in Vision and Ophthalmology Inc.
- Accession number :
- edsair.doi.dedup.....be80a691cf5ba6558ce2c5de33739eff