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Supplementation of nano-bubble curcumin extract improves gut microbiota composition and exercise performance in mice
Supplementation of nano-bubble curcumin extract improves gut microbiota composition and exercise performance in mice
- Source :
- Food & Function. 11:3574-3584
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- Background: In a previous study, we evaluated the potential beneficial effect of nano-bubble curcumin extract (NCE) in reducing exercise-related injuries and improving performance. Methods: In this study, we seek to investigate changes in the gut microbiota composition upon NCE supplementation in relation to health and exercise performance. Male ICR mice were divided into 3 groups (n = 8 per group) and orally administered NCE once daily for six weeks at 0 (vehicle), 3.075 (NCE-1X) and 15.375 g kg−1 day−1 (NCE-5X). The gut microbiota from the mice was analyzed using 16S rRNA gene sequencing. Results: NCE-5X did not appear to obviously cluster with the vehicle group, although NCE-5X groups showed an increased Firmicutes/Bacteroidetes ratio compared with the vehicle group. In addition, anti-fatigue activity and exercise performance were evaluated by investigating the exhaustive swimming time, forelimb grip strength and serum levels of lactate, ammonia, glucose, blood urea nitrogen (BUN), creatine kinase (CK) and lactate dehydrogenase (LDH) after swimming. The NCE-1X and NCE-5X groups showed a significantly longer exhaustive swimming time and higher relative forelimb grip strength than the vehicle group. Tissue glycogen content, an important energy source for exercise, increased significantly with NCE supplementation. Conclusion: Taken together, our results indicate that NCE supplementation alters the gut microbiota composition and aids in overcoming physical fatigue. Curcumin may be acting on the gut microbiome to modulate the gut system towards improving exercise performance.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Curcumin
030209 endocrinology & metabolism
Gut flora
Mice
03 medical and health sciences
Grip strength
chemistry.chemical_compound
0302 clinical medicine
Diarylheptanoids
RNA, Ribosomal, 16S
Lactate dehydrogenase
Internal medicine
Animals
Medicine
Blood urea nitrogen
Fatigue
Mice, Inbred ICR
Glycogen
biology
Plant Extracts
business.industry
General Medicine
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
biology.protein
Creatine kinase
business
Energy source
Food Science
Subjects
Details
- ISSN :
- 2042650X and 20426496
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Food & Function
- Accession number :
- edsair.doi.dedup.....be6a93a6ee97f3d264f6e9090c4f0929
- Full Text :
- https://doi.org/10.1039/c9fo02487e