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Cross-reactive dengue virus antibodies augment Zika virus infection of human placental macrophages
- Publication Year :
- 2018
-
Abstract
- Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies influence ZIKV vertical transmission remains unclear. Here, we find that DENV antibodies increase ZIKV infection of placental macrophages (Hofbauer cells [HCs]) from 10% to over 80% and enhance infection of human placental explants. ZIKV-anti-DENV antibody complexes increase viral binding and entry into HCs but also result in blunted type I interferon, pro-inflammatory cytokine, and antiviral responses. Additionally, ZIKV infection of HCs and human placental explants is enhanced in an immunoglobulin G subclass-dependent manner, and targeting FcRn reduces ZIKV replication in human placental explants. Collectively, these findings support a role for pre-existing DENV antibodies in enhancement of ZIKV infection of select placental cell types and indicate that pre-existing immunity to DENV should be considered when addressing ZIKV vertical transmission.
- Subjects :
- 0301 basic medicine
viruses
Placenta
030106 microbiology
Gene Expression
Dengue virus
Cross Reactions
medicine.disease_cause
Antibodies, Viral
Microbiology
Immunoglobulin G
Article
Zika virus
Dengue fever
Dengue
03 medical and health sciences
Immunity
Interferon
Pregnancy
Virology
medicine
Humans
Antibody-dependent enhancement
biology
Zika Virus Infection
Macrophages
virus diseases
Antibodies, Monoclonal
Zika Virus
biochemical phenomena, metabolism, and nutrition
Dengue Virus
Virus Internalization
biology.organism_classification
medicine.disease
Antibodies, Neutralizing
Antibody-Dependent Enhancement
Infectious Disease Transmission, Vertical
030104 developmental biology
Interferon Type I
biology.protein
Cytokines
Parasitology
Female
Antibody
Chorionic Villi
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....be66eca0262766037b7dc1c2314b6700