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Diabetes in chronic pancreatitis: risk factors and natural history
- Source :
- Curr Opin Gastroenterol
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- PURPOSE OF REVIEW: The purpose of this review is to delineate risk factors for the development of diabetes in patients with chronic pancreatitis. The natural history including progression to diabetes and complications that develop once diabetes occurs in chronic pancreatitis is also reviewed. RECENT FINDINGS: Studies have found that predictors of diabetes in chronic pancreatitis include both risk factors for type 2 diabetes (e.g., obesity, genetic variants) as well as pancreas-specific factors (e.g., pancreatic calcification, exocrine insufficiency). Rates of diabetes in chronic pancreatitis are strongly related to the duration of chronic pancreatitis, reflecting progressive dysfunction and damage to the insulin-secreting beta-cells. Patients with diabetes and chronic pancreatitis experience an excess burden of complications, including higher all-cause and cancer-related mortality. SUMMARY: The high incidence and significant impact of diabetes on the morbidity and mortality of patients with chronic pancreatitis highlights the urgent need for clinically applicable models to predict diabetes in those with chronic pancreatitis, allowing efforts for targeted interventions to prevent diabetes. Research being carried out in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) holds promise to fulfill these goals.
- Subjects :
- medicine.medical_specialty
business.industry
Gastroenterology
Type 2 diabetes
medicine.disease
Obesity
Article
Pancreatic Neoplasms
Natural history
Diabetes Mellitus, Type 2
Risk Factors
Pancreatitis, Chronic
Internal medicine
Diabetes mellitus
Pancreatic cancer
medicine
Humans
Pancreatitis
High incidence
business
Pancreas
Pancreatic calcification
Subjects
Details
- ISSN :
- 15317056 and 02671379
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Gastroenterology
- Accession number :
- edsair.doi.dedup.....be5d4447056b448058af26fdc513f98c