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Gossypol inhibits Ehrlich ascites tumor cell proliferation
- Source :
- Cancer Letters. 24:257-261
- Publication Year :
- 1984
- Publisher :
- Elsevier BV, 1984.
-
Abstract
- Neutral gossypol solution injected peritoneally into NMRI mice preimplanted with Ehrlich ascites tumour cell, at a dose of 25-100 micrograms/mouse per day, lengthened the number of survival days of the hosts. This gossypol effect on tumour cell proliferation is concentration dependent. The optimum dose is 100 micrograms. However, at too high a dose, the gossypol caused a body weight loss and the death of the tumour-bearing mice.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Ratón
Cell
Mice, Inbred Strains
Tumor cells
Biology
Ehrlich ascites
Mice
chemistry.chemical_compound
Internal medicine
medicine
Animals
Carcinoma, Ehrlich Tumor
Dose-Response Relationship, Drug
Cell growth
Body Weight
Gossypol
Concentration dependent
Endocrinology
medicine.anatomical_structure
Oncology
chemistry
Nmri mice
Cell Division
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....be564655535669a991dabfda4d32cd39