Back to Search
Start Over
A 2015 focus on preventing drug-induced arrhythmias
- Source :
- Expert Review of Cardiovascular Therapy, 14(2), 245. Expert Reviews Ltd.
- Publication Year :
- 2015
-
Abstract
- Drug-induced Torsade de Pointes arrhythmia is a life-threatening adverse effect feared by pharmaceutical companies. For the last decade, the cardiac safety guidelines have imposed human ether-a-go-go-related gene channel blockade and prolongation of QT interval as surrogates for proarrhythmic risk propensity of a new chemical entity. Suffering from a lack of specificity, this assessment strategy led to a great amount of false positive outcomes. Therefore, this review will discuss new pharmaceutical strategies: the cardiac safety proposal that recently emerged, the Comprehensive in vitro Proarrhythmia Assay, combining in vitro assays that integrate effects on main cardiac ion channels, with computational models of human ventricular action potential as well as assays using human stem cell-derived cardiomyocytes for an improved prediction of drug’s proarrhythmic liability, alternative pharmacological perspectives as well as the current treatment of drug-induced long QT syndrome.
- Subjects :
- 0301 basic medicine
Drug
Cardiac arrhythmias
medicine.medical_specialty
Long QT syndrome
media_common.quotation_subject
Heart Ventricles
Action Potentials
Review
030204 cardiovascular system & hematology
Research Support
QT interval
drugs
Ion Channels
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Torsades de Pointes
New chemical entity
Internal Medicine
Journal Article
Medicine
Animals
Humans
Computer Simulation
Myocytes, Cardiac
Intensive care medicine
Adverse effect
Non-U.S. Gov't
media_common
Proarrhythmia
business.industry
Research Support, Non-U.S. Gov't
In vitro toxicology
Arrhythmias, Cardiac
General Medicine
medicine.disease
electrophysiology
animal models
Blockade
Long QT Syndrome
030104 developmental biology
cardiac safety
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 17448344 and 14779072
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Expert review of cardiovascular therapy
- Accession number :
- edsair.doi.dedup.....be43dc19c6bb0702d625824d45167a4c