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Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT
- Source :
- Journal of Medicinal Chemistry. 65:15725-15737
- Publication Year :
- 2022
- Publisher :
- American Chemical Society (ACS), 2022.
-
Abstract
- Proteolysis-targeting chimera (PROTAC) is emerging as a promising technology in targeted protein degradation and drug discovery. However, there is still a lack of effective chemical tools to real-time detect and track the protein degradation. Herein, the first fluorescent and theranostic PROTACs were designed for imaging the degradation of nicotinamide phosphoribosyltransferase (NAMPT) in living cells. Compound
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....be42e56dbf04232457c5209e1f52ca7a