Back to Search
Start Over
Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system
- Source :
- Psychopharmacology. 234(3)
- Publication Year :
- 2016
-
Abstract
- The present investigation explored the modulatory role of serotonergic transmission in the acute ethanol-induced effects on immobility time in the mouse forced swim test (FST). Acute i.p. administration of ethanol (20% w/v, 2 or 2.5 g/kg, i.p.) decreased the immobility time in FST of mice, indicating its antidepressant-like effect while lower doses of ethanol (1, 1.5 g/kg, i.p.) were devoid of any effect in the FST. The mice pre-treated with a sub-effective dose of 5-HT2A agonist, DOI (10 μg/mouse, i.c.v.) or 5-HT1A receptor antagonist, WAY 100635 (0.1 μg/mouse, i.c.v.) but not with the 5-HT2A/2C antagonist, ketanserin (1.5 μg/mouse, i.c.v.) exhibited a synergistic reduction in the immobility time induced by sub-effective dose of ethanol (1.5 g/kg, i.p.). On the other hand, ethanol (2.5 g/kg, i.p.) failed to decrease the immobility time in mice, pre-treated with 5-HT1A agonist, 8-OH-DPAT (0.1 μg/mouse, i.c.v.) or ketanserin (1.5 μg/mouse, i.c.v.). In addition, pre-treatment with a 5-HT neuronal synthesis inhibitor, p-CPA (300 mg/kg, i.p. × 3 days) attenuated the anti-immobility effect ethanol (2.5 g/kg, i.p.) in mouse FST. Thus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT1A receptor or contributory role of the 5-HT2A/2C receptor-mediated mechanism is proposed in the anti-immobility effect of acute ethanol in mouse FST.
- Subjects :
- 0301 basic medicine
Agonist
Male
Ketanserin
medicine.drug_class
Pharmacology
Serotonin 5-HT1 Receptor Antagonists
Serotonergic
03 medical and health sciences
Mice
0302 clinical medicine
medicine
Animals
5-HT receptor
Swimming
8-Hydroxy-2-(di-n-propylamino)tetralin
Behavior, Animal
Ethanol
Chemistry
Depression
Amphetamines
Antagonist
Central Nervous System Depressants
Drug Synergism
Serotonin 5-HT1 Receptor Agonists
Receptor antagonist
Antidepressive Agents
030104 developmental biology
Receptor, Serotonin, 5-HT1A
Serotonin 5-HT2 Receptor Antagonists
5-HT1A receptor
030217 neurology & neurosurgery
Serotonin 5-HT2 Receptor Agonists
medicine.drug
Behavioural despair test
Subjects
Details
- ISSN :
- 14322072
- Volume :
- 234
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....be402dd45a572fddaf3c98d41fa44a01