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Relative Efficacy of Nonoperative Treatment of Keratoacanthomas
- Source :
- Journal of cutaneous medicine and surgery. 24(1)
- Publication Year :
- 2019
-
Abstract
- BackgroundKeratoacanthomas (KAs) are neoplasms of squamous epithelium which exhibit rapid growth and are often difficult to distinguish clinically from squamous cell carcinoma. Excision is the most common treatment, but in refractory cases or for KAs in cosmetically sensitive areas, nonoperative modalities may be better suited.ObjectiveTo compare efficacies of topical and intralesional therapies for the treatment of KAs.MethodsA systematic literature review was performed using Medline, Ovid, and Embase. Studies looking at the efficacy of topical or intralesional treatments for KAs were included. To compare efficacy, 2-tailed t-tests were performed, with P < .05 considered statistically significant.ResultsForty-one studies were identified across 5 modalities. Both topical and intralesional treatments had high KA eradication rates (92%-100%). Intralesional 5-fluorouracil led to faster KA healing times when compared to intralesional methotrexate (3.7 vs 4.6 weeks, P = .017). Similarly, topical 5-fluorouracil led to faster time to heal than topical imiquimod (3.8 vs 7.6 weeks with imiquimod, P < .0001).ConclusionFor nonoperative treatment of KAs, strong evidence currently exists for both topical and intralesional therapies. Decisions on which modality to use should be made on a case-by-case basis.
- Subjects :
- Keratoacanthoma
medicine.medical_specialty
Relative efficacy
business.industry
Dermatology
medicine.disease
Conservative Treatment
Skin Diseases
Epithelium
Nonoperative treatment
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
medicine
Humans
Surgery
Basal cell
business
Skin
Subjects
Details
- ISSN :
- 16157109
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cutaneous medicine and surgery
- Accession number :
- edsair.doi.dedup.....be1198a128b36c47e2ae6bc1e1139274