Back to Search
Start Over
Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos
- Source :
- Aquatic toxicology (Amsterdam, Netherlands). 235
- Publication Year :
- 2020
-
Abstract
- Benzophenones are widely used as organic UV filters in many personal care products, especially sunscreen, to protect humans from UV radiation. The increasing use of benzophenone class UV filters has raised concerns about the potential effects on the aquatic environment. These organic UV filters are designed to absorb UV light. However, to date, studies have not considered the potential of UV light to potentiate the toxicity of benzophenones in aquatic organisms. In this study using zebrafish embryos, we assessed the median lethal concentration (LC50) and sub-lethal effects of benzophenone and oxybenzone either under natural levels of UV light or under laboratory light conditions. The LC50 value in zebrafish embryos under both light conditions of oxybenzone was lower when compared to benzophenone. Interestingly, UV light significantly decreased the LC50 values (increased toxicity) of both benzophenone and oxybenzone. The presence of UV light induced a significant increase in hydroxyl radical formation and this was reflected in both increased SOD activity and lipid peroxidation in oxybenzone treated groups. Exposure to either benzophenone or oxybenzone also delayed hatching between 60 and 96 hpf when comparing to the control group while UV exposure further delayed hatching only in oxybenzone-exposed embryos. The results demonstrate the importance of involving UV light in toxicity testing for UV filters and provide much-need information on the UV-induced toxicity of benzophenone and oxybenzone under ecologically realistic conditions.
- Subjects :
- Aquatic Organisms
Embryo, Nonmammalian
Ultraviolet Rays
Health, Toxicology and Mutagenesis
Cosmetics
010501 environmental sciences
Aquatic Science
medicine.disease_cause
01 natural sciences
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
Benzophenones
Ultraviolet light
medicine
Benzophenone
Animals
Zebrafish
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Long-term potentiation
3. Good health
chemistry
13. Climate action
Toxicity
Biophysics
Hydroxyl radical
Oxybenzone
Sunscreening Agents
Oxidative stress
Water Pollutants, Chemical
Subjects
Details
- ISSN :
- 18791514
- Volume :
- 235
- Database :
- OpenAIRE
- Journal :
- Aquatic toxicology (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....be0ce42734120c7a355e3b7270f47553