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Association between Family Histories of Thyroid Cancer and Thyroid Cancer Incidence: A Cross-Sectional Study Using the Korean Genome and Epidemiology Study Data
- Source :
- Genes, Vol 11, Iss 1039, p 1039 (2020), Genes, Volume 11, Issue 9
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group. Trained interviewers questioned the participants to obtain their thyroid cancer history and age at onset. The participants were examined according to their age, sex, monthly household income, obesity, smoking, alcohol consumption, and past medical history. The adjusted odds ratios (95% confidence intervals) for the family histories of fathers, mothers, and siblings were 6.59 (2.05&ndash<br />21.21), 4.76 (2.59&ndash<br />8.74), and 9.53 (6.92&ndash<br />13.11), respectively, and were significant. The results for the subgroup analyses according to sex were consistent. The rate of family histories of thyroid cancer for fathers and siblings were not different according to the thyroid cancer onset, while that of mothers were higher in participants with a younger age at onset (&lt<br />50 years old group, 11/523 [2.1%], p = 0.007). This study demonstrated that thyroid cancer incidence was associated with thyroid cancer family history. This supports regular examination of individuals with a family history of thyroid cancer to prevent disease progression and ensure early management.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Alcohol Drinking
lcsh:QH426-470
Cross-sectional study
differentiated thyroid cancer
030209 endocrinology & metabolism
Article
Papillary thyroid cancer
03 medical and health sciences
0302 clinical medicine
Risk Factors
Epidemiology
Republic of Korea
Genetics
medicine
thyroid cancer
Humans
papillary thyroid cancer
Obesity
Thyroid Neoplasms
Family history
Thyroid cancer
Genetics (clinical)
Aged
Aged, 80 and over
Past medical history
family history
business.industry
Genome, Human
Incidence (epidemiology)
Incidence
Smoking
Odds ratio
Middle Aged
medicine.disease
lcsh:Genetics
Cross-Sectional Studies
030220 oncology & carcinogenesis
Female
epidemiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Volume :
- 11
- Issue :
- 1039
- Database :
- OpenAIRE
- Journal :
- Genes
- Accession number :
- edsair.doi.dedup.....be06c7871f8177a882c7373b861d87ec