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Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response
- Source :
- Clinical Science. 110:93-99
- Publication Year :
- 2005
- Publisher :
- Portland Press Ltd., 2005.
-
Abstract
- The general perception that catabolism and inflammation are associated with a high synthesis rate of total liver protein and a low albumin synthesis rate has been challenged in recent years by several studies in man, indicating that the synthesis rate of albumin in response to a catabolic insult is increased rather than decreased. Thus changes in liver protein synthesis rates in conjunction with catabolism and acute inflammation in man need to be characterized better. The aim of the present study was to measure protein synthesis rates of total liver protein and albumin during a state of acute inflammation. Patients (n=10) undergoing acute laparoscopic cholecystectomy due to acute cholecystitis were investigated. FSRs (fractional synthesis rates) of total liver protein (liver biopsy specimens) and albumin (plasma samples) were investigated as early as possible during the surgical procedure, using a flooding dose of L-[2H5]phenylalanine. The results were compared with a reference group of patients without cholecystitis undergoing elective laparoscopic cholecystectomy (n=17). FSR of total liver protein was 60% higher (P
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Inflammation
Phenylalanine
Gastroenterology
Intraoperative Period
Internal medicine
Cholecystitis
medicine
Humans
Serum Albumin
Aged
Anthropometry
biology
medicine.diagnostic_test
business.industry
Catabolism
Albumin
General Medicine
Middle Aged
biology.organism_classification
medicine.disease
Endocrinology
Cholecystectomy, Laparoscopic
Liver
Protein Biosynthesis
Tasa
Liver biopsy
Acute Disease
Female
Cholecystectomy
medicine.symptom
business
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....be060b7c2f1b8f341d99a145d09ebe69