Back to Search
Start Over
Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease
- Source :
- Inflamm Bowel Dis, Inflammatory bowel diseases, 27(7), 1045-1051. John Wiley and Sons Inc.
- Publication Year :
- 2020
-
Abstract
- Background The neutrophil fecal biomarkers, calprotectin (FCP) and lactoferrin (LCT), and peripheral blood neutrophil CD64 surface receptor (nCD64) are biomarkers for mucosal inflammation in inflammatory bowel disease (IBD). Although FCP has been evaluated as a biomarker for mucosal healing, cut points for LCT and nCD64 are less known. We aimed to identify the cut points for LCT and nCD64 that were associated with FCP remission, with a secondary aim to evaluate the relationship between biochemical outcomes and infliximab (IFX) trough concentrations. Methods We analyzed FCP, LCT, and nCD64 before and after IFX induction in a pediatric Crohn’s disease (CD) cohort study. Week-14 FCP biomarker remission was defined as FCP 17.5 improvement. Predictive outcomes were calculated by receiver operating characteristics (ROCs). Results Among 56 CD patients, ROC analysis identified an infusion 4 LCT 9.4 µg/mL (AUROC, 0.799, P = 0.002) and >11.5 µg/mL (AUROC, 0.835, P = 0.003) were associated with a FCP 5 µg/mL had a median FCP improvement (dose 1 to dose 4) of 90% compared with a median of 35% with levels Conclusions This study establishes cut points in neutrophil stool and blood biomarkers for both biochemical remission and therapeutic trough levels following induction therapy. Further studies that evaluate pharmacodynamic biomarker targets for endoscopic and histologic healing are warranted.
- Subjects :
- medicine.medical_specialty
Neutrophils
Gastroenterology
Inflammatory bowel disease
pediatric Crohn's disease
Cohort Studies
03 medical and health sciences
Feces
0302 clinical medicine
Crohn Disease
Gastrointestinal Agents
Reference Values
Clinical Research
Internal medicine
medicine
Immunology and Allergy
Humans
030212 general & internal medicine
Child
Crohn's disease
Receiver operating characteristic
biology
business.industry
Lactoferrin
Receptors, IgG
medicine.disease
fecal lactoferrin
Infliximab
fecal calprotectin
neutrophil CD64 expression
Pharmacodynamics
biology.protein
Biomarker (medicine)
030211 gastroenterology & hepatology
Calprotectin
business
Leukocyte L1 Antigen Complex
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15364844 and 10780998
- Volume :
- 27
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Inflammatory bowel diseases
- Accession number :
- edsair.doi.dedup.....bde9b8ef1798b920085bd06b2f339582