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Oestradiol Release from Self-setting Apatitic Bone Cement Responsive to Plasma-calcium Level in Ovariectomized Rats, and its Physicochemical Mechanism
- Source :
- Journal of Pharmacy and Pharmacology. 49:1182-1188
- Publication Year :
- 1997
- Publisher :
- Oxford University Press (OUP), 1997.
-
Abstract
- The effect of plasma calcium levels on the release of oestradiol from a self-setting apatite bone cement containing 0.5% oestradiol was investigated in ovariectomized rats. The profiles of in-vitro release from the cements in simulated body fluid containing 0, 5 or 10 mg calcium per 100 mL indicated that the rate of release of oestradiol decreased with increasing calcium concentration in the dissolution media. After subcutaneous implantation of oestradiol-loaded cement in healthy and vitamin D-deficient rats, oestradiol release in diseased rats with low plasma calcium levels was significantly higher than that in healthy rats. These results suggest that in-vitro release of oestradiol from apatite bone cement was dependent on the calcium concentration in the buffer and that the in-vivo release of oestradiol from apatite bone cement was dependent on plasma calcium levels.
- Subjects :
- medicine.medical_specialty
Bone disease
Chemistry, Pharmaceutical
Ovariectomy
Simulated body fluid
Pharmaceutical Science
chemistry.chemical_element
Biocompatible Materials
In Vitro Techniques
Calcium
Drug Delivery Systems
X-Ray Diffraction
Apatites
Internal medicine
medicine
Animals
Rats, Wistar
Pharmacology
Cement
Estradiol
Chemistry
Bone Cements
Vitamin D Deficiency
Bone cement
medicine.disease
Rats
Resorption
Calcium, Dietary
Kinetics
Endocrinology
Area Under Curve
Ovariectomized rat
Liberation
Female
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....bdd8fa2fe9d4c5a16c730a5d5d65bb89