Back to Search
Start Over
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA
- Source :
- Human molecular genetics. 21(9)
- Publication Year :
- 2012
-
Abstract
- Aneurysmal subarachnoid hemorrhage (aSAH) is the most serious subtype of stroke. Genetic factors have been known to play an important role in the development of intracranial aneurysm (IA), some of which further progress to subarachnoid hemorrhage (SAH). In this study, we conducted a genome-wide association study (GWAS) to identify common genetic variants that are associated with the risk of IA, using 1383 aSAH subjects and 5484 control individuals in the Japanese population. We selected 36 single-nucleotide polymorphisms (SNPs) that showed suggestive association (P
- Subjects :
- Genome-wide association study
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Asian People
Japan
Genetics
SNP
Humans
Clinical significance
Genetic Predisposition to Disease
Allele
Molecular Biology
Genetics (clinical)
Cyclin-Dependent Kinase Inhibitor p15
CDKN2BAS
Chromosome
Genetic Variation
Intracranial Aneurysm
General Medicine
Odds ratio
Receptor, Endothelin A
Case-Control Studies
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 9
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14602083
- Volume :
- 21
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Human molecular genetics
- Accession number :
- edsair.doi.dedup.....bdd57e8c1edf2883d72e9dccedda52b0