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Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis
- Source :
- American Journal of Respiratory Cell and Molecular Biology
- Publication Year :
- 2021
- Publisher :
- American Thoracic Society, 2021.
-
Abstract
- Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cellular processes such as apoptosis, senescence, abnormal activation of developmental pathways, aging, as well as genetic mutations. Therefore, targeting the regenerative capacity of the lung epithelium is an attractive approach in the development of novel therapies for IPF. Endogenous lung regeneration is a complex process involving coordinated cross-talk between multiple cell types and re-establishment of a normal extracellular matrix environment. This review will describe the current knowledge of reparative epithelial progenitor cells in the alveolar region of the lung and discuss potential novel therapeutic approaches for IPF focusing on endogenous alveolar repair. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Subjects :
- Pulmonary and Respiratory Medicine
Alveolar Epithelium
Clinical Biochemistry
Idiopathic pulmonary fibrosis
stem cells
medicine
Animals
Humans
Progenitor cell
Lung
Molecular Biology
Cellular Senescence
business.industry
Regeneration (biology)
Interstitial lung disease
Cell Biology
respiratory system
medicine.disease
Idiopathic Pulmonary Fibrosis
respiratory tract diseases
Translational Review
medicine.anatomical_structure
Alveolar Epithelial Cells
regeneration
Cancer research
Stem cell
Lung Diseases, Interstitial
epithelium
Wound healing
business
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi.dedup.....bdd3a2f8de9c3c0351ba2e9b0c45cef8
- Full Text :
- https://doi.org/10.1165/rcmb.2020-0476tr