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Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study
- Source :
- Hicks, B M, Filion, K B, Yin, H, Sakr, L, Udell, J A & Azoulay, L 2018, ' Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer: population-based cohort study ', BMJ, vol. 363, k4209 . https://doi.org/10.1136/bmj.k4209
- Publication Year :
- 2018
- Publisher :
- BMJ, 2018.
-
Abstract
- Objective To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer.Design Population based cohort study.Setting United Kingdom Clinical Practice Research Datalink.Participants A cohort of 992 061 patients newly treated with antihypertensive drugs between 1 January 1995 and 31 December 2015 was identified and followed until 31 December 2016Main outcome measures Cox proportional hazards models were used to estimate adjusted hazard ratios with 95% confidence intervals of incident lung cancer associated with the time varying use of ACEIs, compared with use of angiotensin receptor blockers, overall, by cumulative duration of use, and by time since initiation.Results The cohort was followed for a mean of 6.4 (SD 4.7) years, generating 7952 incident lung cancer events (crude incidence 1.3 (95% confidence interval 1.2 to 1.3) per 1000 person years). Overall, use of ACEIs was associated with an increased risk of lung cancer (incidence rate 1.6 v 1.2 per 1000 person years; hazard ratio 1.14, 95% confidence interval 1.01 to 1.29), compared with use of angiotensin receptor blockers. Hazard ratios gradually increased with longer durations of use, with an association evident after five years of use (hazard ratio 1.22, 1.06 to 1.40) and peaking after more than 10 years of use (1.31, 1.08 to 1.59). Similar findings were observed with time since initiation.Conclusions In this population based cohort study, the use of ACEIs was associated with an increased risk of lung cancer. The association was particularly elevated among people using ACEIs for more than five years. Additional studies, with long term follow-up, are needed to investigate the effects of these drugs on incidence of lung cancer.
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Cohort Studies
Angiotensin Receptor Antagonists
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Risk Factors
Internal medicine
Humans
Medicine
030212 general & internal medicine
Lung cancer
Antihypertensive Agents
2. Zero hunger
biology
business.industry
Proportional hazards model
Incidence
Incidence (epidemiology)
Hazard ratio
Angiotensin-converting enzyme
General Medicine
Middle Aged
medicine.disease
United Kingdom
Confidence interval
Cohort
biology.protein
Female
business
Cohort study
Subjects
Details
- ISSN :
- 17561833 and 09598138
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....bdcfa81eed357694fe8ee772ad41e203