Back to Search
Start Over
TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers
- Source :
- Molecular Medicine Reports.
- Publication Year :
- 2011
- Publisher :
- Spandidos Publications, 2011.
-
Abstract
- Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effects of this polymorphism on pancreatic cancer in relation to smoking and drinking habits by examining the distribution of the SNP genotypes in 226 pancreatic cancer patients and 448 healthy controls. The frequencies of Arg/Arg, Arg/Pro and Pro/Pro were found to be 37, 49 and 15% in the pancreatic cancer cases and 44, 46 and 10% in the controls, respectively. Compared to the controls with the Arg/Arg genotype, cases with Pro/Pro homozygosity exhibited a significantly increased risk [adjusted odds ratio (OR)=1.70; 95% confidence interval (CI) 1.01-2.88]. In stratified studies, the association was particularly strong in males (OR=2.62; 95% CI 1.32-5.23), particularly in those smoking in excess of 20 pack-years and drinking in excess of 23 g ethanol/day (OR=5.02; 95% CI 1.12-22.51). We found that the TP53 Pro/Pro genotype compared to the Arg/Arg genotype had a profound effect on pancreatic cancer risk among males, particularly among heavy smokers and excessive alcohol drinkers.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Alcohol Drinking
Single-nucleotide polymorphism
Biology
medicine.disease_cause
Polymorphism, Single Nucleotide
Biochemistry
Gastroenterology
Risk Factors
Pancreatic cancer
Internal medicine
Genotype
Genetics
medicine
Humans
Genetic Predisposition to Disease
Codon
Molecular Biology
Aged
Oncogene
Smoking
Case-control study
Odds ratio
Middle Aged
medicine.disease
Pancreatic Neoplasms
medicine.anatomical_structure
Oncology
Case-Control Studies
Cancer research
Molecular Medicine
Female
Tumor Suppressor Protein p53
Carcinogenesis
Pancreas
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....bdc5bb8ec04295e7cc10ecd3d88d5671