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Thirteen-Week Oral Dose Toxicity Study of G. bimaculatus in Sprague-Dawley Rats
- Source :
- Toxicological Research
- Publication Year :
- 2011
- Publisher :
- The Korean Society of Toxicology, 2011.
-
Abstract
- Gryllus bimaculatus (Gb) was orally administered at doses of 0, 0.04, 0.2, 1 and 5 g/kg bw/day for 13 consecutive weeks. There were no observed clinical signs or deaths related to treatment in all the groups tested. Therefore, the approximate lethal oral dose of G. bimaculatus was considered to be higher than 5 g/kg in rats. Throughout the administration period, no significant changes in diet consumption, ophthalmologic findings, organ weight, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis) or gross pathology were detected. Minor changes were found in hematological parameters for the 5 g/kg Gb-treated group (triglyceride reduction of 35.8%), but all changes were within normal physiological ranges. Microscopic examination did not identify any treatment-related histopathologic changes in the organs of Gb-treated rats in the high dose group. From these results, one can conclude that the no-observed adverse effect level (NOAEL) of G. bimaculatus is higher than 5 g/kg bw/day in rats.
- Subjects :
- medicine.medical_specialty
Pathology
Hematology
Urinalysis
medicine.diagnostic_test
biology
Triglyceride
Clinical pathology
business.industry
Health, Toxicology and Mutagenesis
Gryllus bimaculatus
G. bimaculatus
13-Week toxicity
Physiology
Articles
Toxicology
biology.organism_classification
Gross examination
chemistry.chemical_compound
chemistry
Internal medicine
Toxicity
Medicine
business
Adverse effect
Subjects
Details
- Language :
- English
- ISSN :
- 19768257
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Toxicological Research
- Accession number :
- edsair.doi.dedup.....bdc4432d466df56e3bf15060e022d21b