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Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women
- Source :
- Psychoneuroendocrinology. 69:116-122
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Cardiovascular stress reactivity is a predictor of atherosclerosis and cardiac events. Dehydroepiandrosterone (DHEA) protects against cardiovascular diseases, but results among previous studies have been inconsistent. We investigated the association between dehydroepiandrosterone-sulfate (DHEA-s) and cardiovascular stress reactivity in Japanese women and men. Among 979 healthy Japanese subjects (641 women and 338 men), serum levels of DHEA-s, systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate, heart rate variability, and peripheral blood flow were measured under rest and two types of task. Mean differences in measured variables during tasks and a post-task period were calculated as changes in stress reactivity. Variables of stress reactivity were adjusted for multiple potential confounding factors. In women, DHEA-s levels showed positive associations with changes in SBP and DBP (standardized beta=0.12, p=0.020; 0.17, 0.002, respectively). Stratification by menopausal status and other lifestyle factors (e.g., smoking status, alcohol consumption) were conducted. Significant positive associations remained in pre-menopausal (standardized beta=0.13, p=0.037; 0.18, 0.005), non-smoking (0.12, 0.010; 0.18
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Dehydroepiandrosterone
Blood Pressure
050105 experimental psychology
Cardiovascular Physiological Phenomena
03 medical and health sciences
chemistry.chemical_compound
Sex Factors
0302 clinical medicine
Endocrinology
Dehydroepiandrosterone sulfate
Japan
Heart Rate
Stress, Physiological
Internal medicine
Heart rate
medicine
Humans
Heart rate variability
0501 psychology and cognitive sciences
Reactivity (psychology)
Life Style
Biological Psychiatry
Dehydroepiandrosterone Sulfate
Endocrine and Autonomic Systems
Smoking
05 social sciences
Confounding
Age Factors
Middle Aged
medicine.disease
Menopause
Psychiatry and Mental health
Blood pressure
chemistry
Cardiovascular Diseases
Hypertension
Female
Psychology
Blood Flow Velocity
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03064530
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Psychoneuroendocrinology
- Accession number :
- edsair.doi.dedup.....bdb2239fe8a0dca316f967498c3ba795