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Fatty acids platelets and oxidative markers following intravenous n-3 fatty acids administration in cystic fibrosis: An open pilot observational study
- Source :
- Journal of Cystic Fibrosis, Journal of Cystic Fibrosis, Elsevier, 2007, 6 (5), pp.320-6. ⟨10.1016/j.jcf.2006.12.005⟩, Journal of Cystic Fibrosis, 2007, 6 (5), pp.320-6. ⟨10.1016/j.jcf.2006.12.005⟩
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- International audience; BACKGROUND: An imbalance in the ratio of arachidonic acid and docosahexaenoic acid (DHA) was found in cystic fibrosis (CF) affected tissues and was suggested to promote inflammation. Several studies have shown that the long chain n-3 fatty acids reduced inflammatory activity while others have highlighted prooxidant activity of DHA at high concentrations. The aim of our study was to evaluate the effects of an intravenous fish-oil emulsion enriched with n-3 FA in patients with CF on plasma and platelet FA composition and peroxidation markers. METHODS: 13 patients with CF received one IV emulsion per week of 2 mL/kg fish-oil n-3 emulsion for 12 weeks. RESULTS: There was a significant increase in 20:5 n-3 and 22:6 n-3 platelet FA composition, no variation in 20:4 n-6, a decrease in n-9. There was no variation in plasma FA composition. Specific urinary markers of lipid peroxidation derived from n-3 and n-6 showed a very high level before infusion compared with usual values in healthy subjects which was not affected by treatment. A significant weight loss and a decrease in reduced glutathione were observed in adult patients. CONCLUSIONS: The intravenous administration of n-3 FA in CF patients induced a significant modification in platelet FA composition but no modification of oxidative markers. However, the weight loss and the decreased level in reduced glutathione observed in adult patients may suggest a potential deleterious activity for some patients. Further studies are necessary to determine the optimal dose and route for long chain FA administration required to reach a potential beneficial effect.
- Subjects :
- MESH: Oxidation-Reduction
030309 nutrition & dietetics
Pilot Projects
030204 cardiovascular system & hematology
medicine.disease_cause
Cystic fibrosis
Lipid peroxidation
chemistry.chemical_compound
0302 clinical medicine
MESH: Fatty Acids, Omega-3
Weight loss
MESH: Child
Platelet
Child
MESH: Blood Platelets
Intravenous fish-oil treatment
0303 health sciences
Fatty Acids
n-3 fatty acids
MESH: Fatty Acids
3. Good health
Biochemistry
Docosahexaenoic acid
Child, Preschool
Injections, Intravenous
Arachidonic acid
medicine.symptom
Oxidation-Reduction
Adult
Blood Platelets
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
MESH: Cystic Fibrosis
03 medical and health sciences
Internal medicine
Fatty Acids, Omega-3
medicine
Humans
Pediatrics, Perinatology, and Child Health
MESH: Adolescent
Glutathione Peroxidase
MESH: Humans
business.industry
MESH: Child, Preschool
MESH: Biological Markers
MESH: Adult
Glutathione
MESH: Pilot Projects
medicine.disease
MESH: Injections, Intravenous
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Endocrinology
chemistry
Oxidative stress
MESH: Glutathione Peroxidase
Pediatrics, Perinatology and Child Health
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biomarkers
Subjects
Details
- ISSN :
- 15691993
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Cystic Fibrosis
- Accession number :
- edsair.doi.dedup.....bdaed8f3810e5179beae9c87e7c04e34