Acoustic Attenuation: Multifrequency Measurement and Relationship to CT and MR Imaging

Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) is gaining significant acceptance as a noninvasive treatment for motion disorders and shows promise for novel applications such as blood-brain barrier opening for tumor treatment. A typical procedure relies on CT-derived acoustic property maps to simulate the transfer of ultrasound through the skull. Accurate estimates of the acoustic attenuation in the skull are essential to accurate simulations, but there is no consensus about how attenuation should be estimated from CT images and there is interest in exploring MR as a predictor of attenuation in the skull. In this study, we measure the acoustic attenuation at 0.5, 1, and 2.25 MHz in 89 samples taken from two ex vivo human skulls. CT scans acquired with a variety of X-ray energies, reconstruction kernels, and reconstruction algorithms, and MR images acquired with ultrashort and zero echo time sequences are used to estimate the average Hounsfield unit value, MR magnitude, and T2* value in each sample. The measurements are used to develop a model of attenuation as a function of frequency and each individual imaging parameter.