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Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention
- Source :
- Current osteoporosis reports. 16(2)
- Publication Year :
- 2018
-
Abstract
- PURPOSE OF REVIEW: Changes in the bone marrow microenvironment, which accompany aging and obesity, including increased marrow adiposity, can compromise hematopoiesis. Here we review deleterious shifts in molecular, cellular and tissue activity, and consider the potential of exercise to slow degenerative changes associated with aging and obesity. RECENT FINDINGS: While bone marrow hematopoietic stem cells (HSC) are increased in frequency and myeloid-biased with age, the effect of obesity on HSC proliferation and differentiation remains controversial. HSC from both aged and obese environment have reduced hematopoietic reconstitution capacity following bone marrow transplant. Increased marrow adiposity affects HSC function, causing up-regulation of myelopoiesis and down-regulation of lymphopoiesis. Exercise, in contrast, can reduce marrow adiposity and restore hematopoiesis. SUMMARY: The impact of marrow adiposity on hematopoiesis is determined mainly through correlations. Mechanistic studies are needed to determine a causative relationship between marrow adiposity and declines in hematopoiesis, which could aid in developing treatments for conditions that arise from disruptions in the marrow microenvironment.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Aging
Endocrinology, Diabetes and Metabolism
Cellular differentiation
Article
03 medical and health sciences
Downregulation and upregulation
Bone Marrow
Internal medicine
medicine
Humans
Lymphopoiesis
Obesity
Exercise
Adiposity
Cell Proliferation
Myelopoiesis
business.industry
Cell growth
Cell Differentiation
Hematopoietic Stem Cells
Hematopoiesis
Haematopoiesis
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Bone marrow
Stem cell
business
Subjects
Details
- ISSN :
- 15442241
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Current osteoporosis reports
- Accession number :
- edsair.doi.dedup.....bdaac74efa632cf421338266d8d9b3f1