Back to Search
Start Over
Low Flucloxacillin Concentrations in a Patient With Central Nervous System Infection
- Source :
- Annals of Pharmacotherapy. 48:1380-1384
- Publication Year :
- 2014
- Publisher :
- SAGE Publications, 2014.
-
Abstract
- Objective: To report the difficulty in achieving and maintaining target antibiotic exposure in critically ill patients with deep-seeded infections. Case Summary: We present a case of a 36-year-old man who was admitted to the intensive care unit with diffuse central nervous system and peripheral methicillin-sensitive Staphylococcus aureus infection (minimum inhibitory concentration; MIC, 1 µg/mL). Owing to the complicated nature of the infection, sequential concentrations of free flucloxacillin were measured in plasma and cerebrospinal fluid (CSF) and used to direct antibiotic dosing. Unsurprisingly, the trough plasma concentrations of flucloxacillin were below the MIC (0.2-0.4 µg/mL), and the corresponding CSF concentrations were undetectable (
- Subjects :
- Adult
Male
Staphylococcus aureus
medicine.drug_class
Critical Illness
Antibiotics
Microbial Sensitivity Tests
Pharmacology
medicine.disease_cause
Floxacillin
law.invention
Cerebrospinal fluid
Pharmacokinetics
Central Nervous System Bacterial Infections
law
medicine
Humans
Pharmacology (medical)
Dosing
Infusions, Intravenous
medicine.diagnostic_test
business.industry
Staphylococcal Infections
Intensive care unit
Anti-Bacterial Agents
Intensive Care Units
Therapeutic drug monitoring
Anesthesia
Flucloxacillin
Drug Monitoring
business
medicine.drug
Subjects
Details
- ISSN :
- 15426270 and 10600280
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Annals of Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....bda71928043dfbd6000fe413f39c0dde