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Interaction between hydroxypropyl methylcellulose and biphasic calcium phosphate after steam sterilisation: capillary gas chromatography studies
- Source :
- Journal of Biomaterials Science, Polymer Edition, Journal of Biomaterials Science, Polymer Edition, Taylor & Francis, 2001, 12 (6), pp.573-9
- Publication Year :
- 2001
- Publisher :
- HAL CCSD, 2001.
-
Abstract
- International audience; The purpose of this study was to check the chemical stability of an injectable bone substitute (IBS) composed of a 50/50 w/w mixture of 2.92% hydroxypropyl methylcellulose (HPMC) solution in deionized water containing biphasic calcium phosphate (BCP) granules (60% hydroxyapatite/40% beta-tricalcium phosphate w/w). After separation of the organic and mineral phases, capillary gas chromatography (GC) was used to study the possible modification of HPMC due to the contact with BCP granules following steam sterilisation and 32 days storage at room temperature. HPMC was extracted from IBS in aqueous medium, and a dialytic method was then used to extract calcium phosphate salts from the HPMC. The percentage of HPMC extracted from BCP was 98.5%+/-0.5%, as measured by UV. GC showed no chemical modifications after steam sterilisation and storage.
- Subjects :
- Calcium Phosphates
MESH: Hydrogen-Ion Concentration
Materials science
Chromatography, Gas
Biomedical Engineering
Biophysics
chemistry.chemical_element
Bioengineering
Biocompatible Materials
Calcium
Methylcellulose
Article
Time
Biomaterials
chemistry.chemical_compound
Hypromellose Derivatives
MESH: Methylcellulose
MESH: Biocompatible Materials
Injectable bone
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Chromatography
Aqueous medium
MESH: Time
MESH: Chromatography, Gas
Temperature
technology, industry, and agriculture
Hydrogen-Ion Concentration
Phosphate
Biphasic calcium phosphate
MESH: Calcium Phosphates
Capillary gas chromatography
MESH: Temperature
body regions
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials
MESH: Salts
chemistry
Chemical stability
Salts
Gas chromatography
Subjects
Details
- Language :
- English
- ISSN :
- 09205063 and 15685624
- Database :
- OpenAIRE
- Journal :
- Journal of Biomaterials Science, Polymer Edition, Journal of Biomaterials Science, Polymer Edition, Taylor & Francis, 2001, 12 (6), pp.573-9
- Accession number :
- edsair.doi.dedup.....bd8ee940de9eb267d846ede42fc71d0f