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FoxO6 regulates memory consolidation and synaptic function
- Source :
- Genes & development, vol 26, iss 24, Genes & development, 26(24), 2780-2801. Cold Spring Harbor Laboratory Press
- Publication Year :
- 2012
- Publisher :
- Cold Spring Harbor Laboratory, 2012.
-
Abstract
- The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) signaling pathway. The most recently discovered FoxO isoform in mammals, FoxO6, is highly enriched in the adult hippocampus. However, the importance of FoxO factors in cognition is largely unknown. Here we generated mice lacking FoxO6 and found that these mice display normal learning but impaired memory consolidation in contextual fear conditioning and novel object recognition. Using stereotactic injection of viruses into the hippocampus of adult wild-type mice, we found that FoxO6 activity in the adult hippocampus is required for memory consolidation. Genome-wide approaches revealed that FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus. Consistently, FoxO6 deficiency results in decreased dendritic spine density in hippocampal neurons in vitro and in vivo. Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory.
- Subjects :
- Male
Aging
Dendritic spine
hippocampus
Hippocampus
Cell Count
FoxO transcription factors
Hippocampal formation
Inbred C57BL
Bioinformatics
Medical and Health Sciences
Mice
Premovement neuronal activity
Cells, Cultured
Cultured
FOXO Family
Forkhead Transcription Factors
Long-term potentiation
Biological Sciences
Impaired memory
Mental Health
Myogenic Regulatory Factors
Neurological
Memory consolidation
learning and memory
Research Paper
Biotechnology
Dendritic Spines
Cells
1.1 Normal biological development and functioning
Biology
Basic Behavioral and Social Science
Memory
Underpinning research
Behavioral and Social Science
Genetics
Animals
synaptic function
insulin signaling
Gene Expression Profiling
Psychology and Cognitive Sciences
Neurosciences
Mice, Inbred C57BL
nervous system
Gene Expression Regulation
Synapses
consolidation
Neuroscience
Gene Deletion
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....bd890d09740b491df89f3ff825fa858c