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Ly49E Expression on CD8αα-Expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases
- Source :
- PLoS ONE, PLOS ONE, PLoS ONE, Vol 9, Iss 10, p e110015 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science, 2014.
-
Abstract
- The Ly49E NK receptor is a unique inhibitory receptor, presenting with a high degree of conservation among mouse strains and expression on both NK cells and intraepithelial-localised T cells. Amongst intraepithelial-localised T cells, the Ly49E receptor is abundantly expressed on CD8 alpha alpha-expressing innate-like intestinal intraepithelial lymphocytes (iIELs), which contribute to front-line defense at the mucosal barrier. Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, have previously been suggested to have an autoreactive origin and to evolve from a dysbalance between regulatory and effector functions in the intestinal immune system. Here, we made use of Ly49E-deficient mice to characterize the role of Ly49E receptor expression on CD8 alpha alpha-expressing iIELs in the development and progression of IBD. For this purpose we used the dextran sodium sulphate (DSS)- and trinitrobenzenesulfonic-acid (TNBS)-induced colitis models, and the TNF Delta ARE ileitis model. We show that Ly49E is expressed on a high proportion of CD8 alpha alpha-positive iIELs, with higher expression in the colon as compared to the small intestine. However, Ly49E expression on small intestinal and colonic iIELs does not influence the development or progression of inflammatory bowel diseases.
- Subjects :
- Receptor expression
PATHOGENESIS
lcsh:Medicine
Cell Count
NK cells
Inflammatory bowel disease
Biochemistry
Immune Receptors
Cellular types
Medicine and Health Sciences
Ileitis
PROTECTION
Lymphocytes
lcsh:Science
Mice, Knockout
INDUCED COLITIS
Multidisciplinary
Immune System Proteins
Dextran Sulfate
Colitis
Ulcerative colitis
CROHNS-DISEASE
Intestines
GAMMA-DELTA-T
Disease Progression
Receptors, Natural Killer Cell
White blood cells
NK CELLS
NK Cell Lectin-Like Receptor Subfamily A
Research Article
Cell biology
Blood cells
Colon
CD8 Antigens
Immune Cells
Immunology
T cells
Immunopathology
Immune system
Killer Activated and Killer Inhibitor Receptors
medicine
Animals
MODULATION
RECEPTOR
Biology and life sciences
business.industry
Tumor Necrosis Factor-alpha
lcsh:R
T-cell receptor
RECOGNITION
Correction
Proteins
Epithelial Cells
medicine.disease
Inflammatory Bowel Diseases
digestive system diseases
Mice, Inbred C57BL
MICE
Trinitrobenzenesulfonic Acid
Animal cells
Intraepithelial lymphocyte
lcsh:Q
Clinical Immunology
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....bd841a2d330d34e8a751756c97bad266