Back to Search
Start Over
Circulating RNA Molecules as Biomarkers in Liver Disease
- Source :
- International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17644-17666 (2014), International Journal of Molecular Sciences
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Liver disease is a major cause of morbidity and mortality worldwide. As in other fields of medicine, there is a stringent need for non-invasive markers to improve patient diagnostics, monitoring and prognostic ability in liver pathology. Cell-free circulating RNA molecules have been recently acknowledged as an important source of potential medical biomarkers. However, many aspects related to the biology of these molecules remain to be elucidated. In this review, we summarize current concepts related to the origin, transportation and possible functions of cell-free RNA. We outline current development of extracellular RNA-based biomarkers in the main forms of non-inherited liver disease: chronic viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver, hepato-toxicity, and liver transplantation. Despite recent technological advances, the lack of standardization in the assessment of these markers makes their adoption into clinical practice difficult. We thus finally review the main factors influencing quantification of circulating RNA. These factors should be considered in the reporting and interpretation of current findings, as well as in the proper planning of future studies, to improve reliability and reproducibility of results.
- Subjects :
- Lung Neoplasms
medicine.medical_treatment
cell-free RNA
diagnostic
Review
Liver transplantation
Biology
Bioinformatics
Catalysis
Inorganic Chemistry
lcsh:Chemistry
Liver disease
Non-alcoholic Fatty Liver Disease
microRNA
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
miRNA
preanalytical variable
Liver Diseases
Organic Chemistry
Fatty liver
RNA
General Medicine
medicine.disease
Prognosis
Computer Science Applications
MicroRNAs
lcsh:Biology (General)
lcsh:QD1-999
Immunology
Biomarker (medicine)
biomarker
Viral hepatitis
liver disease
Biomarkers
Extracellular RNA
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 15
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....bd7b2bba130a20372766d60ca5f70fc8