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The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages
- Source :
- Cell Host & Microbe, Cell Host & Microbe, 2020, 28 (3), pp.390-401.e5. ⟨10.1016/j.chom.2020.06.002⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood. We challenged a murine synthetic bacterial community with phages to study the factors allowing phages-bacteria coexistence. Coexistence was not dependent on the development of phage-resistant clones nor on the ability of phages to extend their host range. Instead, our data suggest that phage-inaccessible sites in the mucosa serve as a spatial refuge for bacteria. From there, bacteria disseminate in the gut lumen where they are predated by luminal phages fostering the presence of intestinal phage populations. The heterogeneous biogeography of microbes contributes to the long-term coexistence of phages with phage-susceptible bacteria. This observation could explain the persistence of intestinal phages in humans as well as the low efficiency of oral phage therapy against enteric pathogens in animal models and clinical trials.
- Subjects :
- Male
Phage therapy
enteroaggregative
medicine.medical_treatment
viruses
[SDV]Life Sciences [q-bio]
murine intestine
Gut flora
medicine.disease_cause
gnotobiotic mice
Microbiology
Predation
03 medical and health sciences
Feces
Mice
0302 clinical medicine
Virology
medicine
Escherichia coli
microbiota
Animals
Germ-Free Life
Bacteriophages
mucosa
Ecosystem
intestinal microbes
030304 developmental biology
0303 health sciences
Mucous Membrane
Oligo mouse microbiota
biology
Bacteria
Ecological dynamics
gut biogeography
biology.organism_classification
Spatial heterogeneity
Gastrointestinal Microbiome
[SDV] Life Sciences [q-bio]
Gastrointestinal Tract
Mice, Inbred C57BL
Models, Animal
Microbial Interactions
Parasitology
Female
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 19313128
- Database :
- OpenAIRE
- Journal :
- Cell Host & Microbe, Cell Host & Microbe, 2020, 28 (3), pp.390-401.e5. ⟨10.1016/j.chom.2020.06.002⟩
- Accession number :
- edsair.doi.dedup.....bd7b1f3a6cef5ac348495243527b8a94