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Trimethyltin-iduced differential expression of PAR subtypes in reactive astrocytes of the rat hippocampus
- Publication Year :
- 2004
- Publisher :
- Mozzon Giuntina S.p.A. - Il Sedicesimo, 2004.
-
Abstract
- Thrombin, its main inhibitor (protease nexin-1) and its related receptors (protease-activated receptors, PAR-1,-2, -3, -4) were studied in rat hippocampus following administration of trimethyltin (TMT), a neurotoxin inducing neuronal degeneration and reactive gliosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry revealed that while expression of prothrombin and protease nexin-1 did not change significantly in TMT-treated hippocampi, PARs (in particular PAR-1 and to a lesser extent PAR-2 and PAR-3) were upregulated in reactive astrocytes, suggesting their involvement in neurodegeneration and in the consequent response of the nervous tissue.
- Subjects :
- Protease-activated receptor
Neurotoxins
Receptors, Proteinase-Activated
Biology
thrombin
protease-activated receptor
astrocyte
trimethyltin
neurotoxicity
neurodegeneration
disorders of the nervous system
Trimethyltin
Hippocampus
Cellular and Molecular Neuroscience
Trimethyltin Compounds
Thrombin
medicine
Neurotoxin
Animals
RNA, Messenger
Neurodegeneration
Rats, Wistar
Receptor
Molecular Biology
Settore BIO/16 - ANATOMIA UMANA
Reverse Transcriptase Polymerase Chain Reaction
Nervous tissue
medicine.disease
Molecular biology
Immunohistochemistry
Rats
Up-Regulation
medicine.anatomical_structure
Biochemistry
Astrocytes
Neuroglia
Astrocyte
Par
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bd683ec31a5fbb7c69bd2dbb2d4b0474