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Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone–Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii
- Source :
- Journal of Natural Products. 80:1944-1947
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- Trichoderpyrone (1), a unique polyketide with a cyclopentenone-pyrone hybrid skeleton, was isolated from the plant endophytic fungus Trichoderma gamsii. The structure of 1 was determined by detailed analysis of NMR data together with comparison of chemical shift values of similar fragments. The relative and absolute configurations were established by NOESY correlations and CD experiment. Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases.
- Subjects :
- Cyclopentenone
Stereochemistry
Pharmaceutical Science
010402 general chemistry
01 natural sciences
Analytical Chemistry
HeLa
Polyketide
chemistry.chemical_compound
Drug Discovery
Botany
Humans
Nuclear Magnetic Resonance, Biomolecular
Trichoderma
Pharmacology
Molecular Structure
biology
010405 organic chemistry
Organic Chemistry
Hep G2 Cells
Plants
Endophytic fungus
biology.organism_classification
Skeleton (computer programming)
Pyrone
0104 chemical sciences
Complementary and alternative medicine
chemistry
Polyketides
Molecular Medicine
Drug Screening Assays, Antitumor
Two-dimensional nuclear magnetic resonance spectroscopy
HeLa Cells
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....bd605af01c18790c223cdf6175418870