High molecular weight adiponectin as a biomarker of hypertension in children and adolescents with obesity

Purpose: To investigate the association of High Molecular Weight Adiponectin (HMW), HMW/ Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and HMW/Adiponectin (APN) ratio with hypertension in obese children and adolescents, we evaluated the concentrations of HMW and HMW/APN in the plasma of obese children and adolescents with hypertension. Methods: The 353 pediatric subjects were grouped according to weight and blood pressure. Anthropometric and biochemical parameters were evaluated. Plasma concentrations of APN and HMW were investigated by ELISA. ANOVA was used to compare study groups, and a binary logistic regression analysis was used to verify if HMW, HMW/HOMA-IR, HMW/APN, APN, APN/HOMA-IR, HOMA-IR are predictors of the development of hypertension in children and adolescents. To compare the strength and performance of each biomarker to classify individuals with and without hypertension, the receiver operating characteristic (ROC) curve, area under the curve (AUC) and Youden index (J) were evaluated. Results: Lower HMW and HMW/HOMA-IR levels were associated with hypertension in obese children and adolescents (P0.05). In the ROC curve analyses, the HMW and HMW/HOM-IR was more sensitive in predicting hypertension in children and adolescents with obese. Conclusion: Low levels of HMW oligomer and HMW/HOM-IR are associated with hypertension in childhood obesity. Thus, theses biomarkers that could be clinically useful in prognosing hypertension in childhood obesity.