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Positive Effects of Soy Isoflavone Food on Survival of Breast Cancer Patients in China
- Source :
- Asian Pacific Journal of Cancer Prevention. 13:479-482
- Publication Year :
- 2012
- Publisher :
- Asian Pacific Organization for Cancer Prevention, 2012.
-
Abstract
- Aim Soy foods are the major source of isoflavones, which are believed to play important roles in genesis of breast cancer and its progression. We here conducted a prospective study to evaluate the association of soy isoflavone food consumption with breast cancer prognosis. Methods A prospective study was performed from January 2004 and January 2006 in China. Trained interviewers conducted face-to-face interviews using a structured questionnaire to collect information on dietary habits and potential confounding factors. The relative risk [hazard ratio (HR)] and 95% CI were calculated from the Cox regression model for all significant predictors from cancer diagnosis to the endpoint of the study (event). Results After a median follow up of 52.1 months (range, 9-60 months), a total of 79 breast cancer related deaths were recorded in our study, risk being inversely associated with a high intake of soy isoflavone. With an average intake of soy isoflavone above 17.3 mg/day, the mortality of breast cancer can be reduced by about 38-36%. We also found the decreased breast cancer death with high soy protein intake, with a HR (95% CI) of 0.71 (0.52-0.98). Stratified analysis with reference to the ER status, further demonstrated a better prognosis of ER positive breast cancer with a high intake of soy isoflavone (HR 0.59, 0.40-0.93). Conclusion Our study shows the soy food intake is associated with longer survival and low recurrence among breast cancer patients. A cohort study with a larger sample size and long term follow-up is now needed.
- Subjects :
- Adult
Oncology
China
Cancer Research
medicine.medical_specialty
Epidemiology
Breast Neoplasms
Breast cancer
Median follow-up
Surveys and Questionnaires
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Survival rate
Soy protein
Gynecology
business.industry
Hazard ratio
Public Health, Environmental and Occupational Health
Soy Foods
Cancer
Feeding Behavior
Middle Aged
Prognosis
medicine.disease
Isoflavones
Postmenopause
Survival Rate
Receptors, Estrogen
Female
business
Follow-Up Studies
Cohort study
Subjects
Details
- ISSN :
- 15137368
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....bd572fa396e3d74599921426c5679c1c