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New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Authors :: Maria C. Teixeira
Andréa Arruda Martins Shimojo
Eliana B. Souto
Selma B. Souto
André F Ribeiro
José L Soriano
Maria Inês Ferreira
Massimo Lucarini
Antonello Santini
Alessandra Durazzo
Beatriz Clares Naveros
Souto, Eliana B
Ribeiro, André F
Ferreira, Maria I
Teixeira, Maria C
Shimojo, Andrea A M
Soriano, José L
Naveros, Beatriz C
Durazzo, Alessandra
Lucarini, Massimo
Souto, Selma B
Santini, Antonello
Universidade do Minho
Source :: International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 2, p 393 (2020), Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
Publication Year :: 2020
Publisher :: MDPI, 2020.
Abstract: Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.<br />The authors would like to thank the financial support received from Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project references M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020, co-financed by FEDER, under the Partnership Agreement PT2020.<br />info:eu-repo/semantics/publishedVersion