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Survival analysis of 219 dogs with hyperadrenocorticism attending primary care practice in England
- Source :
- The Veterinary Record
- Publication Year :
- 2018
-
Abstract
- Background Hyperadrenocorticism is an endocrine disease routinely encountered within primary care practice; however, few studies evaluating survival beyond diagnosis have studied this population. Methods This retrospective cohort study analysed the electronic patient records of 219 cases of hyperadrenocorticism from a sample of dogs attending primary care practices in England. Kaplan-Meier plots examined the cumulative survival and Cox proportional hazard regression modelling identified factors associated with the hazard of all-cause mortality. Results In the analysis, 179/219 (81.7 per cent) hyperadrenocorticism cases died during the study period with a median survival time from first diagnosis of 510 days (95% CI 412 to 618 days). Trilostane was used in 94.1 per cent of cases and differentiation between pituitary-dependent and adrenal-dependent disease was made in 20.1 per cent of cases. In the multivariable analysis, dogs weighing greater than or equal to 15 kg (HR 1.51, 95% CI 1.06 to 2.15, P=0.023) and those diagnosed greater than or equal to 13 years of age (HR 3.74, 95% CI 2.29 to 6.09, P
- Subjects :
- Male
Paper
Pediatrics
medicine.medical_specialty
Adrenocortical Hyperfunction
040301 veterinary sciences
Population
Disease
Primary care
Cumulative survival
survival
0403 veterinary science
Dogs
medicine
Animals
VetCompass
Dog Diseases
education
Survival analysis
Retrospective Studies
education.field_of_study
electronicpatientrecords
Endocrine disease
General Veterinary
Primary Health Care
business.industry
primary-care
0402 animal and dairy science
hyperadrenocorticism
Retrospective cohort study
Dihydrotestosterone
04 agricultural and veterinary sciences
General Medicine
medicine.disease
Prognosis
040201 dairy & animal science
Survival Analysis
England
Female
business
Median survival
Subjects
Details
- ISSN :
- 20427670
- Volume :
- 186
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Veterinary record
- Accession number :
- edsair.doi.dedup.....bd2cd018e07a231bbdb560679ccbdfa4