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Undesired neural side-effects of a drug, a chemical and genetic interrelated problem
- Source :
- Central nervous system agents in medicinal chemistry. 10(2)
- Publication Year :
- 2010
-
Abstract
- Undesired side-effects and toxicities of drugs, especially in the area of new-drug development, are negligibleless, unpredicable and often disastrous once being encountered. Increasing varieties of evidence suggest that the differences of chemical structures of drugs and human's genomic makeup and environmental causes totally decide the occurrences of side-effects and toxicities of drugs instead of chemical structures of a drug alone. The side-effects of central neural systems are relatively easy to be observed and conspicuous and sensitive to judgments with or by fixed grading systems. It could be an important area to systematically study the side-effects of drugs and underlying genetic mechanisms and relationships in between. This review discusses this issue through careful analyzing relevant clinical evidence and published data relating to genetic detection of suffered patients and gives further suggestions to improve.
- Subjects :
- Drug
Bipolar Disorder
Genome
Drug-Related Side Effects and Adverse Reactions
business.industry
General Neuroscience
media_common.quotation_subject
Pharmacology
Deafness
Suicide
Neuropsychology and Physiological Psychology
Risk analysis (engineering)
Clinical evidence
Pharmacogenetics
Drug Design
Molecular Medicine
Neural system
Medicine
Animals
Humans
business
Grading (tumors)
media_common
Subjects
Details
- ISSN :
- 18756166
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Central nervous system agents in medicinal chemistry
- Accession number :
- edsair.doi.dedup.....bd1d46c840d31319dc4a6b761691d197