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Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling
- Source :
- Chemical communications (Cambridge, England). 49(28)
- Publication Year :
- 2013
-
Abstract
- A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes.
- Subjects :
- chemistry.chemical_classification
General method
Bioconjugation
Staining and Labeling
Metals and Alloys
Peptide
General Chemistry
Electrophilic aromatic substitution
Combinatorial chemistry
Catalysis
Cycloaddition
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
chemistry
Furan
Materials Chemistry
Ceramics and Composites
Peptide synthesis
Reactivity (chemistry)
Amino Acid Sequence
Furans
Oligopeptides
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 49
- Issue :
- 28
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....bd1c138e3c3bc8e968c8fd5a23d8a94a