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Urinary protein/creatinine ratio weighted by estimated urinary creatinine improves the accuracy of predicting daily proteinuria
- Source :
- The American journal of the medical sciences. 349(6)
- Publication Year :
- 2015
-
Abstract
- Background The spot urine protein/creatinine ratio (UPCR) is proposed to be a substitute for 24-hour urinary protein (24 h-UP). This study is aimed to determine whether the predictive accuracy of 24 h-UP using UPCR can be improved by simply multiplying estimated daily urine creatinine excretion (eUCr) and UPCR together. Methods This study enrolled 120 participants to investigate the correlation between spot UPCR and 24 h-UP. Three sets of spot urine samples were randomly collected throughout the day and night, along with the first morning void. UPCR was weighted by eUCr to investigate the improvement of accuracy in using spot urine samples to predict 24 h-UP. Results There were strong correlation and concordance between UPCR and 24 h-UP irrespective of the time of spot urine sampling, and the correlation, concordance and agreement were improved after multiplying the UPCR value by the eUCr. Greater improvement was found in the subgroups with measured daily urine creatinine excretion ≤ 0.8 g/d and ≥ 1.2 g/d. Conclusions This investigation demonstrated that multiplying UPCR by eUCr can improve the accuracy of only using UPCR to predict 24 h-UP.
- Subjects :
- Urinary protein
Male
medicine.medical_specialty
Urinary system
Urology
First morning void
Excretion
chemistry.chemical_compound
Predictive Value of Tests
medicine
Humans
Renal Insufficiency, Chronic
Aged
Aged, 80 and over
Creatinine
Proteinuria
business.industry
General Medicine
Middle Aged
Spot urine
chemistry
Predictive value of tests
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 15382990
- Volume :
- 349
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The American journal of the medical sciences
- Accession number :
- edsair.doi.dedup.....bd1189cbf30dffc1a05d05bac4a92355