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Resistance Gene Transfer during Treatments for Experimental Avian Colibacillosis
- Source :
- Antimicrobial Agents and Chemotherapy. 56:189-196
- Publication Year :
- 2012
- Publisher :
- American Society for Microbiology, 2012.
-
Abstract
- An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments—oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)—on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated with rifampin-resistant E. coli strains bearing plasmid genes conferring resistance to fluoroquinolones ( qnr ), cephalosporins ( bla CTX-M or bla FOX ), trimethoprim-sulfonamides, aminoglycosides, or tetracyclines. Feces samples were collected before, during, and after antimicrobial treatments. The susceptibilities of E. coli strains were studied, and resistance gene transfer was analyzed. An increase in the tetracycline-resistant E. coli population was observed only in OTC-treated birds, whereas multiresistant E. coli was detected in the dominant E. coli populations of SXT-, AMX-, or ENR-treated birds. Most multiresistant E. coli strains were susceptible to rifampin and exhibited various pulsed-field gel electrophoresis profiles, suggesting the transfer of one of the multiresistance plasmids from the inoculated strains to other E. coli strains in the intestinal tract. In conclusion, this study clearly illustrates how, in E. coli , “old” antimicrobials may coselect antimicrobial resistance to recent and critical molecules.
- Subjects :
- Gene Transfer, Horizontal
medicine.drug_class
Cephalosporin
Population
Oxytetracycline
Microbial Sensitivity Tests
Drug resistance
Clinical Therapeutics
Biology
medicine.disease_cause
Trimethoprim
Microbiology
Feces
Plasmid
Antibiotic resistance
Drug Resistance, Bacterial
Escherichia coli
medicine
Enrofloxacin
Animals
Pharmacology (medical)
education
Escherichia coli Infections
Pharmacology
education.field_of_study
Bird Diseases
Escherichia coli Proteins
Sulfadimethoxine
Amoxicillin
Antimicrobial
Virology
Anti-Bacterial Agents
Bacterial Typing Techniques
Electrophoresis, Gel, Pulsed-Field
Infectious Diseases
Chickens
Fluoroquinolones
Plasmids
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....bd113b0a51448df8c1811731b07232de