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Ertapenem monotherapy versus combination therapy with ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections in adults
- Source :
- International journal of antimicrobial agents. 20(3)
- Publication Year :
- 2002
-
Abstract
- The efficacy and safety of intravenous (IV) ertapenem, 1 and 1.5 g once a day, for treatment of adults with complicated intra-abdominal infection were compared with those of IV ceftriaxone 2 g once a day plus IV metronidazole 500 mg every 8 h. After at least 3 days of IV therapy and satisfactory clinical response, patients could be switched to oral ciprofloxacin plus metronidazole. Fifty-nine patients were randomized to receive ertapenem 1 g and 51 to receive ertapenem 1.5 g; 55 patients were randomized to each comparator group. At the test of cure, 4-6 weeks post therapy, in the 1 g cohort, 84% (26/31) of patients treated with ertapenem and 85% (35/41) with comparator therapy had a favourable clinical and microbiological assessment. Success rates in the 1.5 g cohort were 83% (22/29) and 77% (24/31) in the ertapenem and comparator groups, respectively. Drug-related adverse events were generally similar in both treatment groups. Ertapenem 1 or 1.5 g once a day followed by optional oral therapy appeared similar to combined therapy with ceftriaxone plus metronidazole with the same optional oral switch for treatment of complicated intra-abdominal infections in adults. Although not compared directly in a randomized fashion, the efficacy and safety profiles of ertapenem 1 and 1.5 g appeared comparable. Ertapenem was generally well tolerated and had an overall safety profile similar to ceftriaxone plus metronidazole.
- Subjects :
- Microbiology (medical)
Adult
Ertapenem
Male
medicine.medical_specialty
Combination therapy
Adolescent
Lactams
beta-Lactams
chemistry.chemical_compound
Pharmacotherapy
Anti-Infective Agents
Double-Blind Method
Internal medicine
Metronidazole
Abdomen
polycyclic compounds
medicine
Humans
Pharmacology (medical)
Adverse effect
Antibacterial agent
Aged
business.industry
Ceftriaxone
General Medicine
Bacterial Infections
Middle Aged
Surgery
Anti-Bacterial Agents
body regions
Ciprofloxacin
Infectious Diseases
chemistry
Injections, Intravenous
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 09248579
- Volume :
- 20
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of antimicrobial agents
- Accession number :
- edsair.doi.dedup.....bd0aa52f1cfc97546283af371dbd239f