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Decreased serum magnesium levels in depression: a systematic review and meta-analysis
- Source :
- Nordic journal of psychiatry. 72(7)
- Publication Year :
- 2018
-
Abstract
- Background: Magnesium (Mg2+), an endogenous N-methyl-D-aspartate receptor antagonist, has received increased attention recently because of its role in the pathophysiology of and treatment response in depression. However, whether Mg2+ level is decreased in depression is not firmly established. We aimed to conduct a systematic review and meta-analysis to help making consensus for the association between Mg2+ levels and depression.Methods: A systematic search was conducted in the electronic database resources PubMed and Embase. After a careful selection of relevant studies, a meta-analysis using the random effects model was conducted in each measuring source, such as serum, plasma, and cerebrospinal fluid (CSF).Results: A total of 18 studies were included in this study. Among 11 studies that measured Mg2+ in the serum, Mg2+ level was lower in patients with depression than in controls (weighted mean difference = −.088, 95% confidence interval = −.164 to −.012). In the sensitivity analysis by removin...
- Subjects :
- Oncology
medicine.medical_specialty
Treatment response
medicine.drug_class
chemistry.chemical_element
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Internal medicine
Medicine
Humans
Magnesium
Psychiatry
Depression (differential diagnoses)
business.industry
Depression
Receptor antagonist
Random effects model
Pathophysiology
Self Concept
030227 psychiatry
Psychiatry and Mental health
chemistry
Meta-analysis
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 15024725
- Volume :
- 72
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nordic journal of psychiatry
- Accession number :
- edsair.doi.dedup.....bd05a1cfc62c3369407ebea190012609