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The effects of Rosmarinus officinalis L. essential oil and its nanoemulsion on dyslipidemic Wistar rats
- Source :
- Journal of Applied Biomedicine. 18:126-135
- Publication Year :
- 2020
- Publisher :
- University of South Bohemia in Ceske Budejovice, 2020.
-
Abstract
- Dyslipidemias are lipid metabolism alterations that cause increased levels of serum lipoprotein, cholesterol, and triglycerides. These alterations are associated with a higher incidence of cardiovascular diseases and are a risk factor for atherosclerosis development. This study aimed to evaluate the effect of Rosmarinus officinalis essential oil (EORO, 100 mg/kg) and its nanoemulsion (NEORO, 500 µg/kg) on Triton and coconut saturated-fat-induced (CSF) dyslipidemias using Wistar rats. The phytochemical evaluation of EORO performed by gas chromatography-mass spectroscopy (GC-MS) revealed 1,8-cineole (33.70%), camphor (27.68%), limonene (21.99%), and α-pinene (8.13%) as its major compounds. Triton-induced dyslipidemia significantly increased total cholesterol, LDL, and triglycerides levels. On the other hand, the groups treated with EORO and NEORO had significantly reduced total cholesterol, LDL, and triglycerides compared to the group treated only with Triton. Similar results were observed on the positive control treated with simvastatin. Dyslipidemia induced with coconut saturated-fat (CSF) caused abdominal fat gain, hypercholesterolemia, hypertriglyceridemia, increased LDL levels, and atherogenesis in the aorta. In contrast, the groups treated with EORO, NEORO, and simvastatin had significantly reduced hypercholesterolemia and hypertriglyceridemia, reduced abdominal fat gain, and absence of atherogenesis in the vascular endothelium. Overall, in the Triton-induced dyslipidemia model, EORO treatment had superior values than NEORO's (and simvastatin), although the differences were not too high, while in the CSF model, the values were mixed. In this manner, our results show an anti-dyslipidemic and anti-atherogenic activity effect by EORO and NEORO.
- Subjects :
- Simvastatin
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Hypercholesterolemia
Biomedical Engineering
General Biochemistry, Genetics and Molecular Biology
Rosmarinus
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Artificial Intelligence
Internal medicine
Oils, Volatile
medicine
Animals
Rats, Wistar
General Pharmacology, Toxicology and Pharmaceutics
Triglycerides
Dyslipidemias
Hypertriglyceridemia
General Immunology and Microbiology
biology
Cholesterol
business.industry
General Neuroscience
nutritional and metabolic diseases
Lipid metabolism
Cholesterol, LDL
General Medicine
Atherosclerosis
medicine.disease
biology.organism_classification
Rats
030205 complementary & alternative medicine
Endocrinology
chemistry
030220 oncology & carcinogenesis
Officinalis
lipids (amino acids, peptides, and proteins)
Nanoparticle Drug Delivery System
General Agricultural and Biological Sciences
business
Dyslipidemia
medicine.drug
Lipoprotein
Subjects
Details
- ISSN :
- 12140287 and 1214021X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Biomedicine
- Accession number :
- edsair.doi.dedup.....bd0595169cc552d8d5a74e97a9c1aea1