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Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2018
- Publisher :
- International Scientific Literature, Inc., 2018.
-
Abstract
- BACKGROUND Obstructive jaundice is a serious, life-threatening condition that can lead to death as a result of sepsis and multiorgan failure due to bacterial translocation. Treatment should be started as soon as possible after diagnosis. MATERIAL AND METHODS Forty 24-week-old male Sprague Dawley rats, with an average weight of 250 g to 300 g, were included in this study. The rats were randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed. CBD ligation was applied to the other groups. After the operation, one CBD group was fed with rat chow only, the others were fed with rat chow supplemented with honey, or immunonutrients, or honey plus immunonutrients. After 10 to 12 days, all rats were sacrificed; blood and tissue samples were collected for biochemical, microbiological, and histopathological evaluation. RESULTS In the groups that were fed with honey and immunonutrients, alanine aminotransferase (ALT) levels were decreased significantly compared to the other groups. Statistically significant differences were detected in terms of bacterial translocation (BT) rates among liver and spleen samples, and laboratory values of serum, except for MLNs of the BDL+HI group, when compared to other groups. We found mean mucosal thickness of ileum samples have been improved notably in the BDL+HI group compared to the other groups, especially compared to the C/BDL group. CONCLUSIONS Immunonutrition applied with honey had immunostimulant effects, decreased BT due to an additive effect, and had positive effects on intestinal mucosa.
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Spleen
Ileum
Immunostimulant
Gastroenterology
digestive system
Sepsis
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Intestinal mucosa
Internal medicine
Medicine
Animals
Intestinal Mucosa
Common bile duct
Microvilli
business.industry
Animal Study
General Medicine
Honey
Jaundice
medicine.disease
digestive system diseases
Intestines
Jaundice, Obstructive
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
Bacterial Translocation
030211 gastroenterology & hepatology
medicine.symptom
business
Ligation
Subjects
Details
- Language :
- English
- ISSN :
- 16433750 and 12341010
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Accession number :
- edsair.doi.dedup.....bceaf2d3e2610c02fe604e34e54b5eaa