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Time to Harmonize Dengue Nomenclature and Classification
- Source :
- Viruses, Viruses, 10 (10, Viruses, Vol 10, Iss 10, p 569 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI, 2018.
-
Abstract
- Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV’s current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Genotype
viruses
lcsh:QR1-502
Dengue virus
Biology
medicine.disease_cause
infectious diseases
lcsh:Microbiology
Dengue fever
law.invention
Dengue
03 medical and health sciences
Antigenic Diversity
SDG 3 - Good Health and Well-being
law
Terminology as Topic
Virology
medicine
Humans
Clade
Pathologie maladies infectieuses
Phylogeny
Genetic diversity
Diversity
Nomenclature
Communication
Outbreak
Genetic Variation
medicine.disease
Classification
3. Good health
030104 developmental biology
Transmission (mechanics)
classification
Evolutionary biology
nomenclature
Sciences pharmaceutiques
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Viruses, Viruses, 10 (10, Viruses, Vol 10, Iss 10, p 569 (2018)
- Accession number :
- edsair.doi.dedup.....bcdf19b0ca8d8fea0cde583ca63e7a84
- Full Text :
- https://doi.org/10.3390/v10100569