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Treatment and monitoring of children with chronic hepatitis C in the Pre-DAA era: A European survey of 38 paediatric specialists
- Source :
- Journal of Viral Hepatitis, Vol. 26, no. 8, p. 961-968 (2019), Journal of Viral Hepatitis, no.April (2019)
- Publication Year :
- 2019
-
Abstract
- The burden of paediatric HCV infection across Europe is unknown, as are current policies regarding monitoring and treatment. This collaborative study aimed to collect aggregate data to characterise the population of ≤18-year olds with HCV infection in specialist follow up in a twelve-month period (2016) across the PENTAHep European consortium, and investigate current policies around monitoring and treatment. A cross-sectional, web-based survey was distributed in April 2017 to 50 paediatricians in 19 European countries, covering patients' profile, and monitoring and treatment practices. Responses were received from 38/50 clinicians collectively caring for 663 children with chronic HCV infection of whom three-quarters were aged ≥6 years and 90% vertically-infected. HCV genotype 1 was the most common (n 380; 57.3%), followed by genotype 3, 4 and 2. Seventeen children (3%) with chronic HCV infection were diagnosed with cirrhosis and 6 were reported to have received liver transplantation for HCV-related liver disease. The majority (n 425; 64.1%) of the European children with HCV infection remained treatment-naive in 2016. Age affected clinicians' attitudes towards treatment; 94% reported being willing to use direct-acting antivirals, if available, in adolescents (aged ≥11 years), 78% in children aged 6-10 and 42% in those 3 to 5 years of age (Pearson correlation coefficient -0.98; p 0.0001). This survey provides the largest characterisation of the population of children in clinical follow-up for chronic HCV infection in Europe, alongside important contextual information on their management and treatment. Discussion is needed around strategies and criteria for use of direct-acting antivirals in these children. This article is protected by copyright. All rights reserved
- Subjects :
- Male
Pediatrics
Cirrhosis
Epidemiology
medicine.medical_treatment
Hepacivirus
Liver transplantation
medicine.disease_cause
Direct-acting antivirals
Liver disease
0302 clinical medicine
030212 general & internal medicine
Europe, direct-acting antivirals, epidemiology, treatment, vertical transmission
Child
education.field_of_study
treatment
Age Factors
Europe
Infectious Diseases
Child, Preschool
Vertical transmission
Female
030211 gastroenterology & hepatology
epidemiology
medicine.medical_specialty
Adolescent
Genotype
Attitude of Health Personnel
Hepatitis C virus
Population
Socio-culturale
Antiviral Agents
03 medical and health sciences
Chronic hepatitis
Hcv genotype 1
Virology
medicine
Humans
Pediatricians
education
direct-acting antivirals
direct-acting antiviral
Hepatology
business.industry
Infant, Newborn
Infant
Hepatitis C, Chronic
medicine.disease
Treatment
Cross-Sectional Studies
Health Care Surveys
vertical transmission
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Viral Hepatitis, Vol. 26, no. 8, p. 961-968 (2019), Journal of Viral Hepatitis, no.April (2019)
- Accession number :
- edsair.doi.dedup.....bcdeba8b54956f795e2e2cbd6a01a508