Back to Search
Start Over
Prediction models to identify hospitalized patients at risk of being colonized or infected with multidrug-resistant Acinetobacter baumannii calcoaceticus complex
- Source :
- The Journal of antimicrobial chemotherapy. 62(5)
- Publication Year :
- 2008
-
Abstract
- Background: The multidrug-resistant (MDR) Acinetobacter baumannii calcoaceticus complex (Abc) has emerged as an important cause of nosocomial infections. The aims of the study were to evaluate risk factors for MDR-Abc in intensive care units (ICUs) as well as in medical and surgical wards, to define the likelihood ratios (LRs) of risk factors and to determine if risk factors differ depending on whether colonization or infections are considered. Methods: Two prospective matched caseācontrol studies were performed. MDR-Abc was defined as a strain resistant to four or more classes of antibiotics. The two case groups included patients with MDR-Abc infections or colonization. Controls were selected among patients not harbouring Abc. Matching criteria were the number of days from admission to MDR-Abc isolation among cases and the duration of hospitalization among controls. Results: Overall, 514 patients were included in the study. One hundred and thirty-seven patients were infected and 120 colonized. A Charlson score >3 and previous methicillin-resistant Staphylococcus aureus isolation and b-lactam use were independent risk factors for colonization and infection. Bedridden status and previous ICU admission were associated with colonization, while the presence of a central venous catheter and surgery were related to infection. The analysis of LRs showed an association between the presence of more than two risk factors and colonization or infection. The highest predicting value was observed for the presence of more than two risk factors and colonization in patients with no history of ICU admission. Conclusions: This study provides novel information that can be used to identify interventions for different stages of the spread of MDR-Abc.
- Subjects :
- Microbiology (medical)
Acinetobacter baumannii
Adult
Male
medicine.medical_specialty
medicine.disease_cause
beta-Lactams
law.invention
Antibiotic resistance
Catheters, Indwelling
Postoperative Complications
law
Risk Factors
Internal medicine
Intensive care
Drug Resistance, Multiple, Bacterial
Medicine
Humans
Pharmacology (medical)
Colonization
Prospective Studies
Intensive care medicine
Antibacterial agent
Aged
Pharmacology
Cross Infection
biology
business.industry
Middle Aged
Staphylococcal Infections
biology.organism_classification
Intensive care unit
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Intensive Care Units
Infectious Diseases
Case-Control Studies
Female
Methicillin Resistance
Acinetobacter calcoaceticus
business
Acinetobacter Infections
Subjects
Details
- ISSN :
- 14602091
- Volume :
- 62
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of antimicrobial chemotherapy
- Accession number :
- edsair.doi.dedup.....bcd7fcfb2f75c039fca7c7a38fba688f