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Synthesis as an Expanding Resource in Human Milk Science
- Source :
- Journal of the American Chemical Society. 143:11277-11290
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- Few classes of natural products rival the structural audacity of oligosaccharides. Their complexity, however, has stood as an immense roadblock to translational research, as access to homogeneous material from nature is challenging. Thus, while carbohydrates are critical to the myriad functional and structural aspects of the biological sciences, their behavior is largely descriptive. This challenge presents an attractive opportunity for synthetic chemistry, particularly in the area of human milk science. First, there is an inordinate need for synthesizing homogeneous human milk oligosaccharides (HMOs). Superimposed on this goal is the mission of conducting syntheses at scale to enable animal studies. Herein, we present a personalized rumination of our involvement, and that of our colleagues, which has led to the synthesis and characterization of HMOs and mechanistic probes. Along the way, we highlight chemical, chemoenzymatic, and synthetic biology based approaches. We close with a discussion on emergent challenges and opportunities for synthesis, broadly defined, in human milk science.
- Subjects :
- 0303 health sciences
Milk, Human
010405 organic chemistry
Chemistry
Scale (chemistry)
Oligosaccharides
Translational research
General Chemistry
01 natural sciences
Biochemistry
Data science
Biological Science Disciplines
Catalysis
0104 chemical sciences
03 medical and health sciences
Synthetic biology
Colloid and Surface Chemistry
Resource (project management)
Homogeneous
Carbohydrate Conformation
Humans
Biological sciences
030304 developmental biology
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....bcc04472ef0bfec8f7709c9a39ecb816