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EZH2 and MMSET Were Identified as Potentially Useful Therapeutic Targets in Metaplastic Breast Carcinoma
- Source :
- Anticancer Research. 40:2133-2139
- Publication Year :
- 2020
- Publisher :
- Anticancer Research USA Inc., 2020.
-
Abstract
- Background/aim Metaplastic breast carcinoma (MBC) is a rare malignancy, which is often triple-negative for the hormone receptors and human epidermal growth factor receptor 2, and thus, does not benefit from targeted therapy. In this study, we examined the expression of methylation and demethylation enzymes by immunostaining MBC and the adjacent normal tissues or triple-negative ductal carcinoma (TNDC), and identified alterations that may be used as therapeutic targets. Materials and methods We retrospectively studied surgical specimens from 15 patients who underwent surgery for MBC at Kanagawa Cancer Center between 2005 and 2016, and similarly from 14 patients with TNDC. The frequencies of high methylation/demethylation enzyme expression were compared among them. Results The frequencies of high enhancer of zeste homolog 2 (EZH2) and multiple myeloma SET domain (MMSET) expression were significantly higher in both MBC and TNDC than in normal tissue. Conclusion EZH2 and MMSET may be useful therapeutic targets in MBC.
- Subjects :
- Adult
Cancer Research
Receptor, ErbB-2
medicine.medical_treatment
Breast Neoplasms
Malignancy
Disease-Free Survival
Targeted therapy
Biomarkers, Tumor
medicine
Humans
Enhancer of Zeste Homolog 2 Protein
skin and connective tissue diseases
Multiple myeloma
Aged
Aged, 80 and over
Metaplasia
business.industry
EZH2
Cancer
Histone-Lysine N-Methyltransferase
General Medicine
Methylation
Middle Aged
Metaplastic Breast Carcinoma
Ductal carcinoma
Prognosis
medicine.disease
Repressor Proteins
Receptors, Estrogen
Oncology
Cancer research
Female
Neoplasm Recurrence, Local
Receptors, Progesterone
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....bcac86816afb3f4cb5288dde611c3fc3
- Full Text :
- https://doi.org/10.21873/anticanres.14172