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EZH2 and MMSET Were Identified as Potentially Useful Therapeutic Targets in Metaplastic Breast Carcinoma

Authors :
Yoshiyasu Nakamura
Kaori Kohagura
Yasushi Rino
Munetaka Masuda
Tatsuya Yoshida
Kae Kawachi
Soji Toda
Hirotaka Nakayama
Nobuyasu Suganuma
Toshinari Yamashita
Takashi Yamanaka
Yuka Matsubara
Yohei Miyagi
Source :
Anticancer Research. 40:2133-2139
Publication Year :
2020
Publisher :
Anticancer Research USA Inc., 2020.

Abstract

Background/aim Metaplastic breast carcinoma (MBC) is a rare malignancy, which is often triple-negative for the hormone receptors and human epidermal growth factor receptor 2, and thus, does not benefit from targeted therapy. In this study, we examined the expression of methylation and demethylation enzymes by immunostaining MBC and the adjacent normal tissues or triple-negative ductal carcinoma (TNDC), and identified alterations that may be used as therapeutic targets. Materials and methods We retrospectively studied surgical specimens from 15 patients who underwent surgery for MBC at Kanagawa Cancer Center between 2005 and 2016, and similarly from 14 patients with TNDC. The frequencies of high methylation/demethylation enzyme expression were compared among them. Results The frequencies of high enhancer of zeste homolog 2 (EZH2) and multiple myeloma SET domain (MMSET) expression were significantly higher in both MBC and TNDC than in normal tissue. Conclusion EZH2 and MMSET may be useful therapeutic targets in MBC.

Details

ISSN :
17917530 and 02507005
Volume :
40
Database :
OpenAIRE
Journal :
Anticancer Research
Accession number :
edsair.doi.dedup.....bcac86816afb3f4cb5288dde611c3fc3
Full Text :
https://doi.org/10.21873/anticanres.14172